BLD 446 Case Study

Elizabeth McEwen is a 47 year old female. She was called back for further imaging following her annual mammogram. It was determined that Elizabeth likely had breast cancer and was immediately referred to an oncologist for treatment. Fine needle biopsy confirmed the breast cancer diagnosis. To personalize her treatment, next-generation sequencing was performed on a portion of the biopsy sample. Interpretation of the next-gen sequencing noted that the tumor did not have BRCA1 or BRCA2 mutation, nor mutation of any of the genes commonly associated with increased breast cancer risk. The only notable mutation in the patient was in the immune gene coding for FcgammaRIII.

For your case study writing assignment this week, answer the following two questions, again with about one paragraph response per question:

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1) Which innate immune cells express FcgammaRIII and what pathway of tumor immunity will lack of FcgammaRIII impact?

2) How will this impact tumor immunosurveillance in this patient?

Finally, be certain to cite any references you use in the case study. Watch out for plagiarism! Any more than a 3-4 word phrase without quotation marks is a strict no-no! Make sure you are interpreting what you read and putting it all in your own words.

Requirements: 400 words

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