Clinical
1.What are the clinical features of a ruptured sinus of Valsalva?
2.Does dobutamine (dose range 2.5-10 μg/kg/min) cause significant
tachycardia?
3.Are beta-blockers indicated in heart failure; if yes, in all cases or in
selected cases?
4.Why does long-term treatment by digitalis cause gynaecomastia?
5.Why do toxic doses of digoxin (which cause a decrease in excitability of
cardiac tissue) cause arrhythmias, whereas therapeutic levels of digoxin
(which cause increase in excitability) cause no arrhythmias?
6.Hypokalaemia is one of the complications of digitalis. In treatment
we give K. How does the hyperkalaemia enhance the digitalis
toxicity?
7.Why should we measure serum potassium before we start digoxin?
8.The intravenous administration of loop diuretics such as furosemide
relieves pulmonary oedema rapidly. Is this due to arteriolar
vasodilatation reducing afterload which is an action that is independent
of its diuretic effect? I ask this because I have been told that this drug has
no effect on arterioles (except on efferent arterioles of the kidney), but
rather a venodilatatory effect. What could be the cause of such different
opinions?
9.There have been a number of recent publications concerning aspirin
versus warfarin trials. Would you recommend prescribing warfarin for
secondary prevention of coronary heart disease in patients suffering from
their first myocardial infarction (MI)?
10 Is it true that in future the ApoA : ApoB ratio will be used to predict
the risk of coronary artery disease more efficiently than low-density
lipoprotein (LDL)?
